情感美文

北京大学生命科学学院

您现在的位置:情感美文 > 情感控制时间2019-07-02 07:03 来源:本站

北京大学生命科学学院

生命科学学院学术报告题目:Mechanicalsignalsmediatedsinglecellspecificationinzebrafishovarianfollicle主讲人:PengXia,时间:2019年6月5日13:00-14:00地点:吕志和楼B106摘要:Forasinglecelltoacquireadifferentfatefromitssurroundingcells,,agroupofcellswithinthegranulosacelllayerattheoocyteanimalpoleacqui,thefuturemicropyleprecursorcell(MPC),accumulatesincreasinglyhighlevelsofnuclearTAZandgrowsfasterthanitssurroundingcells,therebymechanicallycompressingthosecells,,relievingneighbor-cellcompressionbyMPCablationoraspirationrestoresnuclearTAZaccumulationinneighboringcells,,TAZactivitypromotesmTORactivation,IntegrinandKeratin18expression,andextracellularmatrixaccumulation,whichpositivelyfeedbacktosustainTAZhyper-activationintheMPCbyactivatingFAK,Src,,MPCspecificationanditsassociatedfeaturesarealldefectiveintaz-/-ificationbasedonmechanicalforcescontrollingTAZactivity.欢迎各位老师同学积极参加!。

回到顶部